De-extinction startup Colossal Biosciences wants to bring back the woolly mammoth. Well, not the woolly mammoth exactly, but an Asian elephant gene-edited to give it the fuzzy hair and layer of blubber that allowed its close relative to thrive in sub-zero environments. To get to these so-called “functional mammoths,” Colossal’s scientists need to solve a … Read more
Now some key patents have expired, and the US Food and Drug Administration has paved the way for biosimilar versions of insulin—so-called because they’re almost identical to another product already on the market. For a product to be biosimilar, it must be highly similar in structure to the original and work just as well in … Read more
Elon Musk said on the social media platform X on Monday that the first human patient has received a brain implant developed by his company Neuralink. After years of delays, Neuralink started recruiting patients for a clinical trial in the fall after receiving approval from the US Food and Drug Administration and a hospital ethics … Read more
To get the new genetic material into cells, they engineered harmless viruses to carry it. Doctors carefully injected a tiny amount of liquid containing the viruses into a part of the children’s inner ears called the cochlea, a spiral-shaped chamber that contains hair cells. The first patient in the trial received the gene therapy in … Read more
To keep IL-12 inside tumors, scientists at Strand designed a set of instructions called a genetic circuit that tells the mRNA to make the inflammatory protein only when it detects the tumor microenvironment. The circuit is designed to sense levels of microRNA—molecules that naturally regulate gene expression and give off different signatures in cancer cells … Read more
That has led researchers to genetically alter pigs in an attempt to make their organs a better match. The biotech company that bred the pig for the Penn study, eGenesis of Cambridge, Massaschetts, is aiming to do that with gene editing. Scientists at the company used Crispr to make a total of 69 genetic edits … Read more
The purpose of the current trial is to assess the gel’s safety and longevity, not how well it prevents pregnancy. Participants were asked to use a back-up form of birth control while being enrolled in the trial. The gel is designed to dissolve at the end of its lifetime, so the men will be followed … Read more
For Gastón Paladini, pork is a family affair. In 1923, his great-grandfather Don Juan Paladini moved from Italy to Santa Fe, Argentina, where he started putting a South American twist on classic Italian sausage recipes. Eventually, Don Juan’s company became one of Argentina’s largest meat producers. It still bears the family name: Paladini. But in … Read more
It’s been hard recently to think about anything other than the wars and humanitarian crises raging around the world. Climate change has left its mark in what was almost certainly the hottest year in human history—there were unprecedented heat waves, intensified forest fires, torrential rain, and floods like those in Libya that caused devastation after … Read more
In September, Elon Musk’s brain-implant company Neuralink announced the much-anticipated news that it would start recruiting volunteers for a clinical trial to test its device. Known as a brain-computer interface, or BCI, it collects electrical activity from neurons and interprets those signals into commands to control an external device. While Musk has said he ultimately … Read more
