Research led by in part by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) finds that the most common cerebral small-vessel disease feature seen in brain magnetic resonance imaging is a primary vascular factor associated with dementia risk. Results of the major international study emphasize the significance of that … Read more
A new study by investigators from Mass General Brigham suggests that whether a person inherits risk of Alzheimer’s disease from their mother or father influences risk of biological changes in the brain that lead to disease. By evaluating 4,400 cognitively unimpaired adults ages 65-85, the team found those with a history of Alzheimer’s disease (AD) … Read more
People who experience prolonged depressive symptoms starting in young adulthood may have worse thinking and memory skills in middle age, according to a study published in the June 12, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that depressive symptoms were experienced more often by … Read more
A searchable database is now ready to help study Alzheimer’s disease. Neuroscience and biomedical informatics researchers at The Ohio State University Wexner Medical Center and College of Medicine created the comprehensive, user-friendly repository. The free database — known as ssREAD — is outlined in a manuscript published online in Nature Communications. Alzheimer’s disease is the … Read more
It has long been known that a hallmark of Alzheimer’s disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain. During normal disease-free aging, there is also an accumulation of insoluble proteins. To date, approaches to treatments for Alzheimer’s disease have not addressed the contribution of protein insolubility … Read more
Alzheimer’s disease causes significant problems with memory, thinking and behavior and is the most common form of dementia, affecting more than 50 million people around the world each year. This number is expected to triple by the year 2050. Using their own state-of-the art imaging technologies, scientists at the University of California San Diego have … Read more
Dementia is extremely common. According to a 2022 study, a startling 10% of adults in the United States over the age of 65 have dementia, and another 22% have mild cognitive impairment. And dementia risk only increases as we get older: Thirty-five percent of people over the age of 90 are living with dementia. The … Read more
Columbia researchers have discovered a genetic variant that reduces the odds of developing Alzheimer’s disease by up to 70% and may be protecting thousands of people in the United States from the disease. The discovery of the protective variant, which appears to allow toxic forms of amyloid out of the brain and through the blood-brain barrier, … Read more
Familial Alzheimer’s disease can be transferred via bone marrow transplant, researchers show March 28 in the journal Stem Cell Reports. When the team transplanted bone marrow stem cells from mice carrying a hereditary version of Alzheimer’s disease into normal lab mice, the recipients developed Alzheimer’s disease — and at an accelerated rate. The study highlights … Read more
Researchers at the University of Leeds and Lancaster University in the UK have identified a new potential target for the treatment of Alzheimer’s disease — PDE4B. Alzheimer’s disease is the leading cause of dementia and disability in old age. As the number of people diagnosed with Alzheimer’s disease is on the increase, new treatments are … Read more
