Findings suggest ILF3 may function as a reader of telomeric R-loops to help maintain telomere homeostasis
Graphical abstract. Credit: Protein & Cell (2023). DOI: 10.1093/procel/pwad054 Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In a new study, researchers used proximity-dependent biotin identification (BioID) technology to identify the ILF3 interactome and discovered that ILF3 interacts … Read more