The overall principle of the new connectivity enhanced Structure Activity Relation (ceSAR) approach that ranks candidate molecules by their similarity to LINCS analogs with signatures concordant to those of the target gene KDs (left panel), and can be subsequently combined with docking simulations to assess the shape complementarity with specific protein targets (right panel). Credit: … Read more
Jay Austin and members of his research team on R/V Blue Heron prep a meteorological buoy for deployment in western Lake Superior. Image credit: Cait Dettmann/MNSG. Credit: Minnesota Sea Grant For over 11 years Jay Austin and his research team at the University of Minnesota Duluth have carefully tended to a crop of bright-yellow meteorological … Read more
Ray path of K* feature, schematic of the OC heterogeneity, and absolute PKIKP travel time residuals. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adn5562 A doughnut-shaped region thousands of kilometers beneath our feet within Earth’s liquid core has been discovered by scientists from The Australian National University (ANU), providing new clues about the dynamics of our planet’s … Read more
Credit: Pixabay/CC0 Public Domain Since at least Aristotle, writers and scholars have debated what makes for a great story. One of them is Samsun Knight, a novelist who is also an economist and assistant professor of marketing at the University of Toronto’s Rotman School of Management. With a scientist’s tools, he’s done what previous theorizers … Read more
Cumulative occurrence of four extreme heat measures, 2007–2016. Borough abbreviations: BX—The Bronx; BK—Brooklyn; MN—Manhattan; QN—Queens; SI—Staten Island. Credit: Journal of Environmental Economics and Management (2024). DOI: 10.1016/j.jeem.2024.103014 In a revealing piece of research coauthored by a Singapore Management University academic, public policies to ease urban heat in one of the largest first world cities have … Read more
Runners compete in the Falmouth Road Race, Sunday, Aug. 18, 2024, in Falmouth, Mass. Credit: AP Photo/Jeff Roberson Carolyn Baker, clad in a neon pink top and matching sunglasses, smiled as she ran the Falmouth Road Race on the shore of Cape Cod, looking around for friends as she neared the end of a race … Read more
Credit: Unsplash/CC0 Public Domain When it comes to financial reporting, how much information is too much? Public companies in the U.S. file reports every three months to comply with the rules of the Securities and Exchange Commission. Some critics think that’s too often, arguing it focuses companies too much on short-term financial results and too … Read more
In Australia there are with fewer than 3% of men in the early childhood education workforce. Credit: UniSA Step into any early childhood education center, and you’ll encounter a whirlwind of activity: colorful art, energetic play and caring educators shaping young minds. But amid the vibrancy, there’s something often missing … male educators. The lack … Read more
Credit: Yan Krukau from Pexels If you’ve ever opened the door to your child’s room only to be greeted by a sea of clothes, toys and who knows what else, you’re not alone. Among countless reminders, pleading and threats, parents often find themselves in battle with their children when it comes to tidying up. For … Read more
Schematic representation of the upper MVA pathway and summary of the C. necator H16 derivative strains used in this study. Credit: ACS Sustainable Chemistry & Engineering (2024). DOI: 10.1021/acssuschemeng.4c03561 While some microbes can make people sick or spoil food, others are critical for survival. These tiny organisms can also be engineered to make specific molecules. … Read more
