Heart organoids simulate pregestational diabetes-induced congenital heart disease
An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report February 8 in the journal Stem Cell Reports. The organoids recapitulate hallmarks of pregestational diabetes-induced congenital heart disease found in mice and humans. The findings also showed that endoplasmic reticulum (ER) stress and lipid imbalance … Read more
