Urate transporter structures reveal the mechanism behind important drug target for gout
Scientists at St. Jude Children’s Research Hospital have used cryo-electron microscopy to generate ten structures of URAT1, a protein linked to gout. Gout is a type of arthritis caused by excess urate levels, a byproduct of purine metabolism. URAT1 is a transporter that regulates urate levels, controlling its reabsorption in the kidneys. Despite being a … Read more
