GPCR structure: Research reveals molecular origins of function for a key drug target

GPCR structure: Research reveals molecular origins of function for a key drug target

Through an international collaboration, scientists at St. Jude Children’s Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand. They discovered precisely which amino acids control the key pharmacological … Read more