Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer’s disease. They devised a method to study aged neurons in the lab without a brain biopsy, an advancement that could contribute to a better understanding of the disease and new … Read more
Oligodendrocytes are an important source of amyloid beta (Aβ) and play a key role in promoting neuronal dysfunction in Alzheimer’s disease (AD), according to a study published July 23, 2024 in the open-access journal PLOS Biology by Rikesh Rajani and Marc Aurel Busche from the UK Dementia Research Institute at University College London, and colleagues. … Read more
NEW YORK (AP) — Peter Buxtun, the whistleblower who revealed that the U.S. government allowed hundreds of Black men in rural Alabama to go untreated for syphilis in what became known as the Tuskegee study, has died. He was 86. Buxtun died May 18 of Alzheimer’s disease in Rocklin, California, according to his attorney, Minna … Read more
Scientists investigating Alzheimer’s disease have determined the structure of molecules within a human brain for the very first time. Published today in Nature, the study describes how scientists used cryo-electron tomography, guided by fluorescence microscopy, to explore deep inside an Alzheimer’s disease donor brain. This gave 3-dimensional maps in which they could observe proteins, the … Read more
Cambridge scientists have developed an artificially-intelligent tool capable of predicting in four cases out of five whether people with early signs of dementia will remain stable or develop Alzheimer’s disease. The team say this new approach could reduce the need for invasive and costly diagnostic tests while improving treatment outcomes early when interventions such as … Read more
Researchers at the Terasaki Institute for Biomedical Innovation (TIBI) have unveiled a pioneering study shedding light on the intricate mechanisms underlying Alzheimer’s disease (AD). The study, titled “Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype,” represents a significant leap forward in understanding the interplay between amyloid-like structures and neuronal cells. Led by … Read more
A class of proteins that regulates cell repair and enhances cell growth-signaling systems could be a promising new target for the treatment of Alzheimer’s and other neurodegenerative diseases, according to a new study led by researchers at Penn State. They found that disrupting necessary sugar modifications of these proteins promotes cell repair and reverses cellular … Read more
Actor Gena Rowlands, an Emmy and Golden Globe winner best known to modern audiences for her heart-wrenching performance in “The Notebook,” has Alzheimer’s disease. Director and actor Nick Cassavetes, who is Rowlands’ son, confirmed his 94-year-old mother’s diagnosis in an interview with Entertainment Weekly published Tuesday. Rowlands portrayed the older version of Rachel McAdams’ character, … Read more
A scientific story that began with a discovery in just one extraordinary patient is now panning out. In 2019, an international team that included researchers from two Mass General Brigham hospitals — Mass Eye and Ear and Massachusetts General Hospital (MGH) — reported on the case of a patient who did not develop cognitive impairment … Read more
A new study suggests that certain drugs commonly used to treat enlarged prostate may also decrease the risk for dementia with Lewy bodies (DLB). This observational finding may seem surprising, but it mirrors previous work by the University of Iowa Health Care team that links the drugs to a protective effect in another neurodegenerative condition-Parkinson’s … Read more
