Leo Wilson

GPCR structure: Research reveals molecular origins of function for a key drug target

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GPCR structure: Research reveals molecular origins of function for a key drug target

Through an international collaboration, scientists at St. Jude Children’s Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand. They discovered precisely which amino acids control the key pharmacological … Read more

China’s manufacturing activity slows in December in latest sign the economy is still struggling

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China’s manufacturing activity slows in December in latest sign the economy is still struggling

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails A survey of factory managers in China shows that manufacturing contracted in December in the latest sign the world’s No. 2 economy remains sluggish. The official purchasing managers … Read more

Polymers that can kill bacteria

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GPCR structure: Research reveals molecular origins of function for a key drug target

Antibiotic-resistant bacteria have become a rapidly growing threat to public health. Each year, they account for more than 2.8 million infections, according to the U.S. Centers for Disease Control and Prevention. Without new antibiotics, even common injuries and infections harbor the potential to become lethal. Scientists are now one step closer to eliminating that threat, … Read more

Big impacts from small changes in cell

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GPCR structure: Research reveals molecular origins of function for a key drug target

Tiny things matter — for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin. Actin is found in all living cells where it has … Read more

How do painful fibroids grow?

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GPCR structure: Research reveals molecular origins of function for a key drug target

Insights into how uterine tumors grow could give hope to millions of women who deal with painful fibroids. Nearly 8 in 10 women develop fibroids, noncancerous tumors that develop in the uterus during child-bearing years. They can be extremely painful, cause extensive bleeding and lead to infertility. Researchers at the University of Cincinnati found different … Read more

Discovery: Plants use ‘Trojan horse’ to fight mold invasions

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GPCR structure: Research reveals molecular origins of function for a key drug target

UC Riverside scientists have discovered a stealth molecular weapon that plants use to attack the cells of invading gray mold. If you’ve ever seen a fuzzy piece of fruit in your fridge, you’ve seen gray mold. It is an aggressive fungus that infects more than 1,400 different plant species: almost all fruits, vegetables, and many … Read more

What’s next for X and Elon Musk in 2024?

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What’s next for X and Elon Musk in 2024?

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Elon Musk’s tempestuous tenure at X is to continue in 2024 as the billionaire and the social media platform face ongoing issues around online safety regulation, misinformation and … Read more