Leo Wilson

HKDC1 protein found crucial to maintaining two mitochondria subcellular structures, mitochondria and lysosomes

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HKDC1 protein found crucial to maintaining two mitochondria subcellular structures, mitochondria and lysosomes

Overview: Both mitochondrial and lysosomal stress stimulate TFEB nuclear translocation, followed by increased HKDC1 expression. HKDC1 stabilizes PINK1 through interaction with TOM70, thereby facilitating PINK1/Parkin-dependent mitophagy. Additionally, HKDC1 and the VDAC proteins with which it interacts are important for repair of damaged lysosomes and maintaining mitochondria–lysosome contact. HKDC1 prevents DNA damage–induced cellular senescence by maintaining … Read more

Liverpool vs Newcastle LIVE: Premier League team news, line-ups and more tonight as Kieran Trippier absent

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Liverpool vs Newcastle LIVE: Premier League team news, line-ups and more tonight as Kieran Trippier absent

‘We have solutions’ Klopp on Salah as AFCON exit looms Sign up to Miguel Delaney’s Reading the Game newsletter sent straight to your inbox for free Sign up to Miguel’s Delaney’s free weekly newsletter There’s only one New Year’s Day match in the Premier League this year as Liverpool host Newcastle in a tricky encounter … Read more

Israel’s Supreme Court strikes down judicial reforms in blow to Netanyahu

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Israel’s Supreme Court strikes down judicial reforms in blow to Netanyahu

For free real time breaking news alerts sent straight to your inbox sign up to our breaking news emails Sign up to our free breaking news emails Israel’s Supreme Court has struck down a key component of Prime Minister Benjamin Netanyahu’s contentious judicial overhaul, delivering a landmark decision that threatens to reopen the fissures in … Read more

2024 polls: Trump’s lead over Haley in New Hampshire shrinks to within four points

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2024 polls: Trump’s lead over Haley in New Hampshire shrinks to within four points

Related video: Trump claims former White House doctor told him he was healthier than Obama Sign up for the daily Inside Washington email for exclusive US coverage and analysis sent to your inbox Get our free Inside Washington email Former South Carolina governor Nikki Haley is emerging as a strong Republican alternative to Donald Trump, … Read more

‘The trees are trying to tell us things’: the ecologist championing Britain’s ancient forests | Trees and forests

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‘The trees are trying to tell us things’: the ecologist championing Britain’s ancient forests | Trees and forests

Ted Green is a rebel. He calls sheep “land maggots”. A horse-riding centre is “a dog-food complex”. And the ancient tree expert’s new book includes a photo of him sticking up two fingers at a portrait of Margaret Thatcher. But the influential, iconoclastic Green, 89, who has lived his whole life around Windsor Great Park … Read more

Argos January sale 2024: Best deals

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Argos January sale 2024: Best deals

Sign up to our free weekly newsletter for insider tips and product reviews from our shopping experts Sign up for our free IndyBest email If you missed the chance to bag a bargain in the Boxing Day sales, you can more than make up for it in the January sales. The Argos January sale sees … Read more

How farmers in the Sahel grow crops with little to no water

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How farmers in the Sahel grow crops with little to no water

(a) In Mboro, Meouane Department, Senegal, Modou Fall has carved up his onion plot with little indentations to keep manure and water supplies concentrated at the roots; (b) in Medina Yoro Foulah, Kolda Department, Senegal, this grower has transplanted his aubergines into pockets filled with organic matter. His method helps significantly reduce water consumption by … Read more